TECHNO CHEMICAL corp.

ポリサイエンス社製品
cat.#14489-25

DODAP (1,2-dioleoyl-3-dimethylammonium propane)

Key Features - High transfection efficiency and low cytotoxicity - Efficient delivery of plasmid DNA, siRNA/miRNA, and CRISPR/Cas9 components - Widely used in nanomedicine - Flexible and scalable DODAP (1,2-dioleoyl-3-dimethylammonium-propane) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7). The electrostatic interactions between DODAP and naturally occurring anionic lipids in endosomal membranes trigger the release of nucleic acid. These interactions promote membrane lytic non-bilayer structures to enable the intracellular delivery of nucleic acid. A common application is in nanomedicine as an ionizable lipid component of nanocarriers (lipid-polymer hybrid nanoparticles, LPNs), widely used to encapsulate bioactive molecules, including mRNA, siRNA, and plasmid DNA as a treatment for diseases. APPLICATION(S): DNA, SiRNA, mRNA transfection, Drug delivery, Gene therapy SHIPPING REQUIREMENTS: Dry Ice:

製品リスト

Cat.#	容量	定価
14489-25	25 mg	¥22,200
14489-100	100 mg	¥53,000
14489-500	500 mg	¥153,000

CAS	127512-29-2
M.W.：	648.05
保管温度＆取扱：	-20℃
出荷温度：	ドライアイス出荷

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